Given the frequency with which CBD is consumed, it is logical to assume that the body will react in the same way that it does with substances such as tea, coffee or sugar.
Although there is much more at play when it comes to tolerance than just three mechanisms, studies so far suggest that CBD does not develop tolerance. What’s more, it can reduce the activation of CB1 receptors, without the endocannabinoid system having to desensitize. The potential for this interaction is significant, as the compound may also reduce side effects and the development of tolerance to other cannabinoids.